ENZYME ENGINEERING
Building a green and more efficient industry
through computing
Nostrum Biodiscovery can create an enhanced enzyme tailored to your particular needs through its proprietary in silico enzyme evolution methodology and molecular modeling on mutated enzyme candidates. PELE efficiently maps the interactions between an enzyme and its substrate highlighting key residues.
In Silico Directed Evolution
In silico Enzyme Directed Evolution allows us to quickly test tens of thousands of mutant variants in short time, reproducing (and expanding) months of work in an experimental lab for just a few hours of computational time. The combination of PELE with powerful computational resources leads to a massive space screening.
PluriZyme | 
One enzyme, one active site. NBD breaks the dogma. Through our computational approach, we can introduce artificial fully functional active sites, crafting PluriZymes, a breakthrough in Biotechnology.
Computational Bioprospecting
Using our methodology, we can select the best enzymes from large databases. Computational Bioprospecting will save weeks of experiments using a combination of different computational tools.
Consumer Goods companies are using enzymes in their production processes and as part of the final products (detergents, foods & beverages, cosmetics & hygiene products). Moreover, enzymes are widely used as part of the production chain since they are more environmentally- friendly and efficient. Finding and evolving enzymes with enhanced properties is key to improve products and productivity in industry.
Unfortunately, most of the industrial waste is dumped into the residual waters. Furthermore, pig slurry treatment limits the meat industry growth. Finally, accumulation of non-degradable plastics, low paper reutilization efficiency and lignocellulosic biomass deposition represents a huge headache for governments. Enzymes can be designed to degrade these widespread contaminants into non-toxic waste, or even to valuable components; the only sustainable long-term solution.
Biomass for Biofuels, Fertilizers, Livestock or Paper is undergoing a revolution. Enzyme Engineering is improving production systems, making some of them already profitable. The Lignocellulosic market is experiencing a huge demand increase due to the developments in terms of machinery and enzyme performance; there are needs for increasing the percentage of profits in regards to costs.
A part of these sectors, our Enzyme Engineering services are adaptable to all industrial sectors demanding it. Biotechnology companies, the chemical sector and the textile industry are other sectors where NBD’s expertise has been proved.
Enhanced Enzymes & PluriZymes
| USE | IN SILICO EVOLUTION | EXPERIMENTAL VALIDATION | INDUSTRIAL SET UP | LICENSING | Co-developers | |
|---|---|---|---|---|---|---|
| NBC-01 | BIOETHANOL PRODUCTION |
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| NBC-02 | LIGNIN DEGRADATION |
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| NBC-03 | UNDISCLOSED |
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PluriZymes; breaking the dogma
One enzyme, one active site. NBD breaks the dogma. Through our computational approach, we can introduce artificial fully functional active sites, crafting PluriZymes, a breakthrough in Biotechnology.
PluriZymes; breaking the dogma
