In plain language: Fourteen research groups of the Ascona B-DNA Consortium, including Nostrum scientists and our President Modesto Orozco, simulated all 2,080 possible six-letter DNA sequences in atomic detail, generating 0.25 petabytes of data. The results reveal a hidden physical code: how the sequence of DNA shapes its flexibility and movement, beyond the genetic code itself.
Why it matters to clients: This open, validated dataset helps build better AI and coarse-grained models of DNA, strengthening how nucleic-acid targets and therapeutics can be modelled.
Published in Nature Communications, hexABC characterizes the 2,080 DNA hexamers embedded in 190 carefully selected duplexes, each simulated in replicate for at least 10 microseconds. The analysis captures sequence-dependent DNA properties, including rare events such as backbone transitions and partial unfolding, and the data are released following FAIR principles.
Read the full article in Nature Communications: https://doi.org/10.1038/s41467-026-74390-5
