New paper in Nucleic Acid Research : “Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism”
We are happy to share that our Nucleic Acid Director, Vito Genna, has published a new paper in Nucleic Acid Research : “Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism”
🔬 The findings unveil a remarkable inclination—of both the human genome and transcriptome—to generate hybrid triplex formation, particularly within untranslated (UTRs) and regulatory regions, thereby corroborating the existence of a triplex-mediated regulatory mechanism. Furthermore, a correlation between nucleosome linkers and Triplex-forming sequence (TFS) was found, which agree with a putative role of triplexes in arranging chromatin structure.
🥼 from our Director of Nucleic Acids, @Vito Genna :
Our latest publication in Nucleic Acids Research uncovers the stability and regulatory potential of hybrid DNA-RNA triplex structures, shedding new light on RNA-mediated DNA regulation. Using computational and experimental approaches, we establish a stability hierarchy and develop a predictive model for triplex formation. These findings open new avenues for therapeutic innovation, offering potential strategies for targeted gene regulation in the pharmaceutical field and paving the way for novel RNA-targeting drug development.
🔗 link to the paper:
https://lnkd.in/d5WvnK9C
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